Crespi & Badcock/Psychosis and Autism: BBS Call for Commentators

Dear Dr. Qwerty, ================================================================== *** CALL RESPONSE INSTRUCTIONS *** ================================================================== Please DO NOT respond to this email. Please note that this is NOT a formal invitation. If you wish to submit a proposal for commentary and/or suggest potential commentators, please go to the Online Commentary Proposal System at the following URL: http://www.bbsonline.org/perl/commentary/commproposal?authordir=Crespi-0216… * If you only wish to suggest potential commentators, please ignore prompts to submit a proposal with expertise information. * If you experience technical difficulties, please email bbs(a)bbsonline.org. * Please respond to this Call no later than November 7, 2007 NOTE: Behavioral and Brain Sciences (BBS) is an international, interdisciplinary journal providing Open Peer Commentary on important and controversial current research in the biobehavioral and cognitive sciences. Commentators must be BBS Associates, or suggested by a BBS Associate. If you are not a BBS Associate, please follow the instructions linked below: http://www.bbsonline.org/Instructions/associnst.html ================================================================== ** Target Article Information ** ================================================================== To help you decide whether you would be an appropriate commentator for this article, an unedited, uncorrected target article is retrievable at the URL that follows the abstract and keywords below. This unedited draft has been prepared only for potential commentators who wish to nominate themselves for formal commentary invitation. Please DO NOT write a commentary until you receive a formal invitation. If you are invited to submit a commentary, a copyedited, corrected version of this paper will be posted in the invitation letter. The commentary invitation list is compiled by the Editors so as to balance proposals, areas of expertise, and frequency of prior commentaries in BBS. TITLE: Psychosis and Autism as Diametrical Disorders of the Social Brain AUTHORS: Bernard Crespi and Christopher Badcock ABSTRACT: Autistic-spectrum conditions and psychotic-spectrum conditions (mainly schizophrenia, bipolar disorder, and major depression) represent two major suites of disorders of human cognition, affect and behavior that involve altered development and function of the social brain. We describe evidence that a large set of phenotypic traits exhibit diametrically-opposite phenotypes in autistic-spectrum vs. psychotic-spectrum conditions, with a focus on schizophrenia. This suite of traits is inter-correlated, in that autism involves a general pattern of constrained overgrowth, whereas schizophrenia involves undergrowth. These disorders also exhibit diametric patterns for traits related to social brain development, including aspects of gaze, agency, social cognition, local vs. global processing, language, and behavior. Social cognition is thus under-developed in autistic-spectrum conditions, and hyper-developed on the psychotic spectrum. We propose and evaluate a novel hypothesis that may help to explain these diametric phenotypes: that the development of these two sets of conditions is mediated in part by alterations of genomic imprinting. Evidence regarding the genetic, physiological, neurological and psychological underpinnings of psychotic spectrum conditions support the hypothesis that the etiologies of these conditions involve biases towards increased relative effects from imprinted genes with maternal expression, which engender a general pattern of undergrowth. By contrast, autistic-spectrum conditions appear to involve increased relative bias towards effects of paternally-expressed genes, which mediate overgrowth. This hypothesis provides a simple yet comprehensive theory, grounded in evolutionary biology and genetics, for understanding the causes and phenotypes of autistic-spectrum and psychotic-spectrum conditions. KEYWORDS: autism, cognition, genomic conflict, genomic imprinting, psychosis, schizophrenia, hyper-mentalism FULL TEXT: http://www.bbsonline.org/Preprints/Crespi-02162007/Referees/ ================================================================== *** CALL RESPONSE INSTRUCTIONS *** ================================================================== Please DO NOT respond to this email. Please note that this is NOT a formal invitation. If you wish to submit a proposal for commentary and/or suggest potential commentators, please go to the Online Commentary Proposal System at the following URL: http://www.bbsonline.org/perl/commentary/commproposal?authordir=Crespi-0216… * If you only wish to suggest potential commentators, please ignore prompts to submit a proposal with expertise information. * If you experience technical difficulties, please email bbs(a)bbsonline.org. * Please respond to this Call no later than November 7, 2007 NOTE: Behavioral and Brain Sciences (BBS) is an international, interdisciplinary journal providing Open Peer Commentary on important and controversial current research in the biobehavioral and cognitive sciences. Commentators must be BBS Associates, or suggested by a BBS Associate. If you are not a BBS Associate, please follow the instructions linked below: http://www.bbsonline.org/Instructions/associnst.html ================================================================== ================================================================== Barbara Finlay - Editor Paul Bloom - Editor Behavioral and Brain Sciences bbs(a)bbsonline.org http://www.bbsonline.org -------------------------------------------------------------------