================================================================== *** CALL RESPONSE INSTRUCTIONS *** ================================================================== Please DO NOT respond to this email. Please note that this is NOT a formal invitation. If you wish to submit a proposal for commentary and/or suggest potential commentators, please go to the Online Commentary Proposal System at the following URL: http://www.bbsonline.org/perl/commentary/commproposal?authordir=Redish-0928… * If you only wish to suggest potential commentators, please ignore prompts to submit a proposal with expertise information. * If you experience technical difficulties, please email bbs(a)bbsonline.org. * Please respond to this Call no later than January 28, 2008 NOTE: Behavioral and Brain Sciences (BBS) is an international, interdisciplinary journal providing Open Peer Commentary on important and controversial current research in the biobehavioral and cognitive sciences. Commentators must be BBS Associates, or suggested by a BBS Associate. If you are not a BBS Associate, please follow the instructions linked below: http://www.bbsonline.org/Instructions/associnst.html ================================================================== ** Target Article Information ** ================================================================== To help you decide whether you would be an appropriate commentator for this article, an unedited, uncorrected target article is retrievable at the URL that follows the abstract and keywords below. This unedited draft has been prepared only for potential commentators who wish to nominate themselves for formal commentary invitation. Please DO NOT write a commentary until you receive a formal invitation. If you are invited to submit a commentary, a copyedited, corrected version of this paper will be posted in the invitation letter. The commentary invitation list is compiled by the Editors so as to balance proposals, areas of expertise, and frequency of prior commentaries in BBS. TITLE: A unified framework for addiction: Vulnerabilities in the decision process AUTHORS: A. David Redish, Steve Jensen, Adam Johnson ABSTRACT: The understanding of decision-making systems has come together in recent years to form a unified theory of decision-making in the mammalian brain as arising from multiple, interacting systems (a planning system, a habit system, and a situation-recognition system). This unified decision-making system has multiple potential access points through which it can be driven to make maladaptive choices, particularly choices which entail seeking of certain drugs or behaviors. We identify ten key vulnerabilities in the system: (1) moving away from homeostasis, (2) changing allostatic set points, (3) euphorigenic “reward-like” signals, (4) overvaluation in the planning system, (5) incorrect search of situation-action-outcome relationships, (6) misclassification of situations, (7) overvaluation in the habit system, (8) a mismatch in the balance of the two decision systems, (9) over-fast discounting processes, and (10) changed learning rates. These vulnerabilities provide a taxonomy of potential problems with decision-making systems. Although each vulnerability can drive an agent to return to the addictive choice, each vulnerability will also produce a characteristic symptomology. Different drugs, different behaviors, and different individuals are likely to access different vulnerabilities. This has implications for an individual’s susceptibility to addiction and the transition to addiction, for the potential for relapse, and for the potential for treatment. KEYWORDS: addiction, gambling, decision-making, striatum, hippocampus, frontal cortex, dopamine FULL TEXT: http://www.bbsonline.org/Preprints/Redish-09282006/Referees/ ================================================================== *** CALL RESPONSE INSTRUCTIONS *** ================================================================== Please DO NOT respond to this email. Please note that this is NOT a formal invitation. If you wish to submit a proposal for commentary and/or suggest potential commentators, please go to the Online Commentary Proposal System at the following URL: http://www.bbsonline.org/perl/commentary/commproposal?authordir=Redish-0928… * If you only wish to suggest potential commentators, please ignore prompts to submit a proposal with expertise information. * If you experience technical difficulties, please email bbs(a)bbsonline.org. * Please respond to this Call no later than January 28, 2008 NOTE: Behavioral and Brain Sciences (BBS) is an international, interdisciplinary journal providing Open Peer Commentary on important and controversial current research in the biobehavioral and cognitive sciences. Commentators must be BBS Associates, or suggested by a BBS Associate. If you are not a BBS Associate, please follow the instructions linked below: http://www.bbsonline.org/Instructions/associnst.html ================================================================== ================================================================== Paul Bloom - Editor Barbara Finlay - Editor Behavioral and Brain Sciences bbs(a)bbsonline.org http://www.bbsonline.org -------------------------------------------------------------------