Dear All,
The CEU Department of Cognitive Science and the Center for Cognitive Computation (CCC)
invites you to the upcoming meeting of the Budapest Computational Neuroscience
Forum<https://ccc.ceu.edu/budapest-computational-neuroscience-forum>um>.
Speaker: András Ecker, EPFL
Long-term plasticity induces sparse and specific synaptic changes in a biophysically
detailed cortical model
Abstract: Synaptic plasticity underlies the brain's ability to learn and adapt. This
process is often studied in small groups of neurons in vitro or indirectly through its
effects on behavior in vivo. Due to the limitations of available experimental techniques,
investigating synaptic plasticity at the microcircuit level relies on simulation-based
approaches. Although modeling studies provide valuable insights, they are usually limited
in scale and generality. To overcome these limitations, we extended a previously published
and validated large-scale cortical network model with a recently developed calcium-based
model of functional plasticity between excitatory cells. We calibrated the network to
mimic an in vivo state characterized by low synaptic release probability and low-rate
asynchronous firing, and exposed it to 10 different stimuli. We found that synaptic
plasticity sparsely and specifically strengthened synapses forming spatial clusters on
postsynaptic dendrites and those between populations of co-firing neurons, also known as
cell assemblies: among 312 million synapses, only 5% experienced noticeable plasticity and
cross-assembly synapses underwent three times more changes than average. Furthermore, as
occasional large-amplitude potentiation was counteracted by more frequent synaptic
depression, the network remained stable without explicitly modeling homeostatic
plasticity. When comparing the network's responses to the different stimuli before and
after plasticity, we found that it became more stimulus-specific after plasticity,
manifesting in prolonged activity after selected stimuli and more unique groups of neurons
responding exclusively to a single pattern. Taken together, we present a plasticity rule
that leads to sparse change and analyze the rules governing those changes.
Time: 17:00, November 15., 2023.
Location: CEU, 1051 Budapest, Nádor u. 15, Room 203. and Zoom (Meeting ID: 957 1381
9303<https://ceu-edu.zoom.us/j/95713819303?pwd=SzM0b1NIU0ZUbzBOUkRpeVc0ME1kQT09>
Passcode: 367015)
Should you have any inquiries about the series, please contact Mihály
Bányai<mailto:mihaly.s.banyai@gmail.com>.
Best regards,
Ildikó
Ildikó Varga
Department Coordinator (Budapest)
Department of Cognitive Science
[cid:19577c97-0d6c-4255-b849-7cca23b147b8]
H-1051 Budapest
Nador u. 15. FT room 404
tel: +36-1 327-3000 2941
http://www.ceu.edu<http://www.ceu.edu/>
http://cognitivescience.ceu.edu<http://cognitivescience.ceu.edu/>
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